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It is an oxidoreductase with a redox-active disulphide/dithiol at the active site [105,122]

The international guidelines for the diagnosis and management of COPD

doi: 10.1371/journal.pone.0003119 25 GemenetziM.LoteryA

Eur J Pharmacol 966:176341

To determine whether GSSG-induced TNF hepatotoxicity is associated with inhibition of the NF-B signaling pathway, we first examined the effects of H 2 O 2 , BCNU, and diamide treatment on TNF-stimulated NF-B activation